Clinical Resources

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Clinical Abstracts

  • Breast Cancer

    2016

    • Two-year Follow-up Results of a Multi-center Trial of Intra-operative Electronic Brachytherapy During Breast Conservation Surgery for Early Stage Breast Cancer
      A.M. Nisar Syed. Two-year Follow-up Results of a Multi-center Trial of Intra-operative Electronic Brachytherapy During Breast Conservation Surgery for Early Stage Breast Cancer. Presented at SABCS 2016.
    • Multi-center Trial of Intra-operative Electronic Brachytherapy During Breast Conservation Surgery for Early Stage Breast Cancer: Early Results of Unplanned Boost Participants
      A.M. Nisar Syed. Multi-center Trial of Intra-operative Electronic Brachytherapy During Breast Conservation Surgery for Early Stage Breast Cancer: Early Results of Unplanned Boost Participants. Presented at SABCS 2016
    • Early Results of a Multi-Center Trial of Intra-Operative Radiation Therapy Using Electronic Brachytherapy at the Time of Breast Conservation Surgery for Early Stage Breast Cancer
      A.M. Nisar Syed, et al. Early Results of a Multi-Center Trial of Intra-Operative Radiation Therapy Using Electronic Brachytherapy at the Time of Breast Conservation Surgery for Early Stage Breast Cancer. Presented at ASTRO 2016.
    • Early Results of a Multi-Center Trial of Intra-Operative Radiation Therapy Using Electronic Brachytherapy at the Time of Breast Conservation Surgery for Early Stage Breast Cancer
      P. Costa, et al. Early Results of a Multi-Center Trial of Intra-Operative Radiation Therapy Using Electronic Brachytherapy at the Time of Breast Conservation Surgery for Early Stage Breast Cancer. Presented at ESTRO 2016.

    2015

    • Feasibility and Early Outcomes of a Multi-Center Trial Of Intraoperative Radiation Therapy Using Electronic Brachytherapy At The Time Of Breast Conservation Surgery For Early Stage Breast Cancer
      A.M. Nisar Syed, et al. Feasibility and Early Outcomes of a Multi-Center Trial Of Intraoperative Radiation Therapy Using Electronic Brachytherapy At The Time Of Breast Conservation Surgery For Early Stage Breast Cancer. Presented at ASTRO 2015.
    • Five-Year Results of a Multi-Center Trial Utilizing Xoft Axxent Electronic Brachytherapy to Deliver Intraoperative Radiation Therapy in the Treatment of Early-Stage Breast Cancer
      A. Dickler, et al. Five-Year Results of a Multi-Center Trial Utilizing Xoft Axxent Electronic Brachytherapy to Deliver Intraoperative Radiation Therapy in the Treatment of Early-Stage Breast Cancer. Presented at ASTRO 2015.
    • Feasibility and Early Outcomes of a Multi-Center Trial of Intra-Operative Radiation Therapy Using Electronic Brachytherapy at the Time of Breast Conservation Surgery for Early Stage Breast Cancer
      A.M. Nisar Syed, et al. Feasibility and Early Outcomes of a Multi-Center Trial of Intra-Operative Radiation Therapy Using Electronic Brachytherapy at the Time of Breast Conservation Surgery for Early Stage Breast Cancer. Presented as snap oral presentation at ABS 2015.
    • One-year Follow-up Results of a Multi-Center Trial of Intraoperative Radiation Therapy Using Electronic Brachytherapy at the Time of Breast Conservation Surgery for Early Stage Breast Cancer
      A.M. Nisar Syed, et al. One-year Follow-up Results of a Multi-Center Trial of Intraoperative Radiation Therapy Using Electronic Brachytherapy at the Time of Breast Conservation Surgery for Early Stage Breast Cancer. Presented at SABCS 2015.
    • Initial Results of a Multi-center Trial Utilizing Xoft Axxent Electronic Brachytherapy to Deliver Intraoperative Radiation Therapy in the Treatment of Early-stage Breast Cancer
      A Dickler, et al. Initial Results of a Multi-center Trial Utilizing Xoft Axxent Electronic Brachytherapy to Deliver Intraoperative Radiation Therapy in the Treatment of Early-stage Breast Cancer.

    2014

    • Early Breast Cancer Treated with Electronic Intraoperative Radiotherapy System (IORT): Report of the First Patients Treated in Portugal
      P. Costa, et al. Early Breast Cancer Treated with Electronic Intraoperative Radiotherapy System (IORT): Report of the First Patients Treated in Portugal. Presented at ISIORT 2014.

    2009

    • APBI: RSNA preliminary report of 44-patient study results
      Mehta, VK. "Early Experience With an Electronic Brachytherapy Technique for Intracavitary Partial Breast Irradiation." RSNA 2009: Abstract.

    2008

    • APBI: ASCO Breast Cancer Symposium—Preliminary report of 44-patient study results
      Mehta V, Dooley W, Greim K, et al. "Early Experience With an Electronic Brachytherapy Technique for Intracavitary Partial Breast Irradiation." ASCO Breast Cancer Symposium 2008; Poster presentation December 2008.
  • Skin Cancer

    2016

    • Clinical Outcomes and Patient Reported Outcomes Following Electronic Brachytherapy for the Treatment of Non-Melanoma Skin Cancer
      A. Bhatnagar. Clinical Outcomes and Patient Reported Outcomes Following Electronic Brachytherapy for the Treatment of Non-Melanoma Skin Cancer. Presented at ASTRO 2016.
    • Peri-ocular non-melanoma skin cancers: Outcome in 62 cases treated with High Dose Rate Electronic Brachytherapy
      N. Flores. Peri-ocular non-melanoma skin cancers: Outcome in 62 cases treated with High Dose Rate Electronic Brachytherapy. Presented at AAD 2016.

    2015

    • Electronic Brachytherapy for the Treatment of Non-Melanoma Skin Cancer: Results up to 5 Years
      A. Bhatnagar. Electronic Brachytherapy for the Treatment of Non-Melanoma Skin Cancer: Results up to 5 Years. Presented at ASTRO 2015.
    • Clinical and Cosmetic Outcomes in Patients Treated With High Dose Rate Electronic Brachytherapy for Nonmelanoma Skin Cancer
      P. Sanghvi. Clinical and Cosmetic Outcomes in Patients Treated With High Dose Rate Electronic Brachytherapy for Nonmelanoma Skin Cancer. Presented at ASTRO 2015.
    • Long-Term Follow-up of Patients with Non-melanoma Skin Cancer (NMSC) Lesions Treated with Electronic Brachytherapy
      R. Strimling, et al. Long-Term Follow-up of Patients with Non-melanoma Skin Cancer (NMSC) Lesions Treated with Electronic Brachytherapy. Presented at the Fall Clinical Dermatology Conference 2015.
    • Electronic Brachytherapy for Non-Melanomatous Skin Cancer: Report of First 565 Lesions
      S. Doggett, et al. Electronic Brachytherapy for Non-Melanomatous Skin Cancer: Report of First 565 Lesions. Presented at AAD 2015.
    • Initial Experience of Electronic Brachytherapy for the Treatment of 494 Non-melanoma Skin Cancer (NMSC) Lesions in 297 Patients
      R. Strimling, et al. Initial Experience of Electronic Brachytherapy for the Treatment of 494 Non-melanoma Skin Cancer (NMSC) Lesions in 297 Patients. Presented at AAD 2015.
    • Electronic Brachytherapy for the Treatment of Non-Melanoma Skin Cancer: Results up to 5 Years
      A. Bhatnagar. Electronic Brachytherapy for the Treatment of Non-Melanoma Skin Cancer: Results up to 4 Years. Presented at AAD 2015.
    • Electronic Brachytherapy for Non-Melanomatous Skin Cancer: Report of Failures and Adverse Events; Annual Follow-Up Report of First 565 Lesions
      S. Doggett, et al. Electronic Brachytherapy for Non-Melanomatous Skin Cancer: Report of Failures and Adverse Events; Annual Follow-Up Report of First 565 Lesions. Presented as snap oral presentation at ABS 2015.
    • A Multi-Center Report of Non-Surgical Treatment of Non- Melanomatous Skin Cancer with HDR Electronic Brachytherapy
      R. Patel, et al. A Multi-Center Report of Non-Surgical Treatment of Non- Melanomatous Skin Cancer with HDR Electronic Brachytherapy. Presented as snap oral presentation at ABS 2015.
    • Initial Experience with Electronic Brachytherapy for Skin Cancer: Clinical and Dosimetric Comparisons
      R. Patel, et al. Initial Experience with Electronic Brachytherapy for Skin Cancer: Clinical and Dosimetric Comparisons. Presented at ABS 2015.
    • Electronic Brachytherapy Management of Atypical Fibroxanthoma: Report of 7 Cases
      S. Doggett. Electronic Brachytherapy Management of Atypical Fibroxanthoma: Report of 7 Cases.

    2014

    • Electronic Brachytherapy for the Treatment of Non-Melanoma Skin Cancer: Results up to 4 Years
      A. Bhatnagar. Electronic Brachytherapy for the Treatment of Non-Melanoma Skin Cancer: Results up to 4 Years. Presented at ASTRO 2014.
    • Initial Experience of Electronic Brachytherapy for the Treatment of 508 Non-melanoma Skin Cancer (NMSC) Lesions in 305 Patients
      R. Strimling, et al. Initial Experience of Electronic Brachytherapy for the Treatment of 508 Non-melanoma Skin Cancer (NMSC) Lesions in 305 Patients. Presented at the Fall Clinical Dermatology Conference 2014.
    • Electronic Brachytherapy for Non-Melanomatous Skin Cancer: Report of First 561 Lesions
      S. Doggett. Electronic Brachytherapy for Non-Melanomatous Skin Cancer:Report of First 561 Lesions.
    • Electronic Brachytherapy for Non-Melanomatous Skin Cancer: Report of First 561 Lesions
      S. Doggett, et al. Electronic Brachytherapy for Non-Melanomatous Skin Cancer: Report of First 561 Lesions.
  • Gynecological Cancers

    2013

    • First report of using a 50 kV electronic-source brachytherapy for cervical cancer and was accomplished with acceptable dosimetry and clinical tolerability
      JS Thompson, et al. First report of using a 50 kV electronic-source brachytherapy for cervical cancer and was accomplished with acceptable dosimetry and clinical tolerability. Presented at ASTRO 2013.
  • Physics & Dosimetry

     

Published Clinical Data

  • Breast Cancer

    2012

    • Follow-up paper with 1-2 year updates to the initial paper by Beitsch et al in OT&T 2010.
      Patel RR, Beitsch PD, Nichols TD, et al. Postsurgical Treatment of Early-stage Breast Cancer with Electronic Brachytherapy: Outcomes and Health-related Quality of Life at 1 Year. Am J Clin Oncol 2012 Jun 14.

    2011

    • APBI: Retrospective study reporting clinical outcomes and a dosimetric comparison of Xoft versus Ir-192 following the treatment of early-stage breast cancer
      Dooley WC, Wurzer JC, Megahy M, et al. "Electronic Brachytherapy as Adjuvant Therapy for Early Stage Breast Cancer: A Retrospective Analysis." OncoTargets and Therapy 2011;4:13-20.
    • Description of lumpectomy technique and reports similar outcomes to Iridium based balloon brachytherapy for APBI.
      Dooley WC, Algan O, Dowlatshahi K, et al. Surgical Perspectives from a Prospective Nonrandomized Multicenter Study of Breast Conserving Surgery and Adjuvant Electronic Brachytherapy for the Treatment of Breast Cancer. World J Surg Oncol 2011;9:30.

    2010

    • APBI: The EXIBT Registry initial interim analysis of one-year follow-up data demonstrating safety and efficacy using Xoft as an adjuvant radiation therapy for early-stage breast cancer
      Beitsch, PD, Patel RR, Lorenzetti JD, et al. "Post-surgical Treatment of Early-stage Breast Cancer With Electronic Brachytherapy: An Intersociety, Multicenter Brachytherapy Trial." OncoTargets and Therapy (3) 2010: 211–218.
    • APBI: Initial experience using Xoft eBx for the treatment of early-stage breast cancer; one-year follow-up is reported
      Mehta VK, Algan O, Greim K, et al. "Experience With an Electronic Brachytherapy Technique for Intracavitary Accelerated Partial Breast Irradiation." American Journal of Clinical Oncology (4:33) August 2010: 327–335.
    • Multi-center study of post surgical treatment of early stage breast cancer with eBx
      Beitsch, PD, Patel RR, Lorenzetti JD, et al. Post-surgical Treatment of Early-Stage Breast Cancer with Electronic Brachytherapy: An Intersociety, Multicenter Brachytherapy Trial. Onco Targets Ther 2010;3:211-218.

    2009

    • IORT: Detailed description of how to treat patients using the Xoft system intra-operatively at time of lumpectomy for the treatment of early-stage breast cancer
      Dickler A, Ivanov O, Francescatti D. "Intraoperative Radiation Therapy in the Treatment of Early-Stage Breast Cancer Utilizing Xoft Axxent Electronic Brachytherapy." World Journal of Surgical Oncology (7) 2009: 24.
  • Skin Cancer

    2017

    • Does ultrasound measurement improve the accuracy of electronic brachytherapy in the treatment of superficial non-melanomatous skin cancer?
      Uma Goyal, MD, Journal of Contemporary Brachytherapy (2017/volume 9/number 1)
    • Electronic brachytherapy management of atypical fibroxanthoma: report of 8 lesions
      Author – Stephen Doggett, MD,. Journal of Contemporary Brachytherapy (2017/volume 9/number 1)

    2016

    • Non-melanoma skin cancer treated with high-dose-rate brachytherapy: a review of literature
      Author – Delishaj 2016. Journal of Contemporary Brachytherapy (2016/volume 8/number 6)
    • Dose Rate Electronic Brachytherapy: A Non-surgical Treatment Alternative for Non-melanoma Skin Cancer
      R. Patel, et al. Dose Rate Electronic Brachytherapy: A Non-surgical Treatment Alternative for Non-melanoma Skin Cancer. Journal of Clinical and Aesthetic Dermatology Vol. 9, No. 11, November 2016.

    2015

    • Clinical and cosmetic outcomes in patients treated with high dose rate electronic brachytherapy for nonmelanoma skin cancer
      A. Paravati et al. Clinical and cosmetic outcomes in patients treated with high dose rate electronic brachytherapy for nonmelanoma skin cancer. Journal of Practical Radiation Oncology
    • Incorporation of Electronic Brachytherapy for Skin Cancer into a Community Dermatology Practice
      S. Doggett, et al. Incorporation of Electronic Brachytherapy for Skin Cancer into a Community Dermatology Practice. Journal of Clinical and Aesthetic Dermatology (Nov. 2015)

    2013

    • Case report demonstrating successful treatment of a patient with squamous cell carcinoma in situ of the dorsal-distal finger.
      Arterbery VA, Watson AC. An electronic brachytherapy technique for treating squamous cell carcinoma in situ of the digit: a case report. BMC Research Notes 2013;6:147.
    • Treatment of 171 NMSC lesions in 122 patients was effective with no recurrences, good to excellent cosmesis, and acceptable toxicities at 1 year.
      Bhatnagar A. Nonmelanoma Skin Cancer Treated with Electronic Brachytherapy: Results at 1 year. Brachytherapy 2013;12:134-140.

    2010

    • Clinical outcomes of patients with non-melanoma skin cancer treated with eBx: acute safety, efficacy, and cosmesis are reported
      Bhatnagar A, Loper A. "The Initial Experience of Electronic Brachytherapy for the Treatment of Non-melanoma Skin Cancer." Radiation Oncology (5:87) 2010: 1–8.
  • Gynecological Cancers

    2013

    • eBx is acceptable for post operative vaginal brachytherapy and comparable with other methods with low toxicity rates
      Kamrava M, Chung MP, DeMarco J, et al. Electronic brachytherapy for postsurgical adjuvant vaginal cuff irradiation therapy in endometrial and cervical cancer: a retrospective study. Brachytherapy 2013;12:141-147.

    2010

    • Multi-center study reporting success of treatment delivery, safety and acute outcomes of patients treated with eBx for early-stage endometrial cancer post TAH-BSO
      Dickler A, Puthawala MY, Thropay JP, et al. "Prospective Multi-Center Trial Utilizing Electronic Brachytherapy for the Treatment of Endometrial Cancer." Radiation Oncology (5:67) 2010: 1–6.
    • Retrospective study evaluates feasibility and safety of Xoft system as a post-surgical adjuvant radiation therapy for the treatment of endometrial cancer
      Dooley WC, Thropay JP, Schreiber GJ, et al. "Use of Electronic Brachytherapy to Deliver Post-Surgical Adjuvant Radiation Therapy for Endometrial Cancer: A Retrospective Multicenter Study." OncoTargets and Therapy (3) 2010: 197–203.
  • Physics & Dosimetry

    2010

    • A comparison of the treatment plans for patients treated with eBx using the Axxent system as adjuvant therapy for early-stage breast cancer with treatment plans prepared from the same CT image sets using an Iridium-192 source
      Ahmad S, Johnson D, Hiatt JR, Still T, Furhang EE, Marsden D, Kearly F, Bernard DA, Holt RW. "Comparison of Tumor and Normal Tissue Dose for Accelerated Partial Breast Irradiation Using Electronic Brachytherapy eBx source and an Iridium-192 source." J Appl Clin Med Phys (11:4) 2010: 155–161.
    • Comprehensive calibration procedures for medical physicists for using the Xoft eBx system and skin applicators for non-melanoma skin cancer treatments
      Rong Y, Welsh JS. "Surface Applicator Calibration and Commissioning on the Xoft Electronic Brachytherapy for Non-melanoma Skin Cancer Treatment." Med Phys (37:10) 2010: 5509–5510.
    • Various balloon-insertion orientations to optimize skin surface dose are simulated
      Hepel JT, Hiatt JR, Cardarelli GA, et al. "Modeling Study for Optimization of Skin Dose for Partial Breast Irradiation Using Xoft Axxent Electronic Brachytherapy Applicator." Brachytherapy (9) 2010: 81–85.
    • Dosimetric comparison of eBx versus Ir-192 in APBI application
      Mille MM, Xu XG. "Comparison of Organ Doses For Patients Undergoing Balloon Brachytherapy of The Breast With HDR 192Ir or Electronic Sources Using Monte Carlo Simulations in a Heterogeneous Human Phantom." Medical Physics (37) 2010: 662–671.

    2009

    • Point-counterpoint discussion
      Sternick E, Todor D, Orton C. "Intensity Modulated Electronic Brachytherapy Will Soon Become The Brachytherapy Treatment of Choice For Irregularly Shaped Tumor Cavities or Those Closely Bounded by Critical Structures." Medical Physics (36) 2009: 681–683.

    2008

    • Electronic source will ultimately replace Ir-192 as the source for HDR Brachytherapy
      Holt RW, Thomadsen BR, Orton CG. "Mini-X-ray Tubes Will Ultimately Displace Ir-192 as The Radiation Source for High Dose-Rate Brachytherapy." Medical Physics (35) 2008: 815–817.
    • Measurements of X-ray spectra and half-value layers for the Axxent source, operating at 40 and 50 kV, are compared with Monte Carlo calculations using Geant4
      Reniers B, Liu B, Rusch T, et al. "Calculation of RBE of a Low-Energy Electronic Brachytherapy Source." Physics in Medicine and Biology (53) 2008: 7125–7135.
    • Calculations and measurements of TG-43 source parameters
      Mahesh M, Detorie N, Holt R, et al. "Electronic Brachytherapy: Comparisons With External Beam and High Dose-Rate 192Ir Brachytherapy." Journal American College Radiology (5) 2008: 221–223.
    • Procedures used at Rhode Island Hospital to commission the Xoft system
      Hiatt JR, Cardarelli GA, Hepel J, et al. "A Commissioning Procedure for Breast Intracavitary Electronic Brachytherapy Systems." Journal of Applied Clinical Medical Physics (9) 2008: 58–68.
    • Dosimetric comparison Xoft versus Ir-192
      Dickler A, Kirk MC, Coon A et al. Dosimetric Comparison of Xoft Electronic Brachytherapy and Ir-192 HDR Brachytherapy In the Treatment of Endometrial Cancer. Brachytherapy 2008; 7;351-354.
    • Measurements of X-ray spectra and half-value layers for the Axxent source, operating at 40 and 50 kV, are compared with Monte Carlo calculations using Geant4
      Liu D, Poon E, Bazalova M, et al. "Spectroscopic Characterization of a Novel Electronic Brachytherapy System." Physics in Medicine and Biology (53) 2008: 61–78.

    2007

    • Dosimetric comparison Xoft versus Ir-192
      Dickler, et al. "A Dosimetric comparison of MammoSite high dose rate brachytherapy and Xoft Axxent electronic brachytherapy," Brachytherapy (6) 2007, 164-168.
    • Dose volume characteristics of the 50kV source
      Smitt MC, Kirby R. "Dose Volume Characteristics of a 50kV Electronic Brachytherapy Source For Intracavitary Accelerated Partial Breast Irradiation." Brachytherapy (6) 2007: 207–211.

    2006

    • The Xoft System is described along with calculations and measurements of TG-43 source parameters
      Rivard M, Davis S, DeWerd L, et al. "Calculated and Measured Brachytherapy Dosimetry Parameters For The Xoft Axxent X-Ray Source: An Electronic Brachytherapy Source." Medical Physics (33) 2006: 4020–4032.

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